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Updated: May 11, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
[Thrombosis of the pelvic and leg--conservative procedure or thrombolytic therapy?]
Elko Randrianarisoa1, Kilian Rittig, Klaus Brechtel
1Medizinische Klinik-Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen. elko.randrianarisoa@med.uni-tuebingen.de
History And Admission Findings:
We report on a young female patient with flank pain and a swelling of the lower limb of the left side.
Investigations:
In magnetic resonance angiography as well as Doppler-duplex ultrasound an iliofemoral phlebothrombosis of the left side due to vena cava inferior hypoplasia with collateral circulation was diagnosed. Oral contraception could play a role as a trigger. The patient also presented activated protein C resistance/ heterozygous factor V Leiden mutation.
Diagnosis, Treatment And Course:
According to the CaVenT study we treated the patient successfully with catheter-directed thrombolysis. Follow-ups presented a patency of the iliofemoral vein.
Conclusions:
In young patients with short duration of a proximal deep vein thrombosis and after exclusion of contraindications a catheter-directed lysis should be considered as a treatment option. The differential diagnostic of a (bilateral) ilio-femoral vein thrombosis in young patients should include an anomaly of the venous system.
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