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Stimulated Single Fiber Electromyography (SFEMG) for Assessing Neuromuscular Junction Transmission in Rodent Models
Published on: March 8, 2024
Single-fiber electromyography in amyotrophic lateral sclerosis and cervical spondylosis
Mingsheng Liu1, Liying Cui, Yuzhou Guan
1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Introduction:
Cervical spondylosis (CS) is a common disease in adults and may coexist with amyotrophic lateral sclerosis (ALS). It is important to detect ALS coexisting with CS (ALS-cs) at an early stage, especially when surgical treatment of CS is planned.
Methods:
Single-fiber electromyography was performed in 26 patients with ALS, 19 with ALS-cs, and 22 with CS.
Results:
Mean jitter, percentage of jitter >55 μs, and percentage of impulse blocking were not statistically different between ALS and ALS-cs cases, but they were significantly lower in CS. Mean fiber density was not statistically different among the 3 groups. The percentage of pairs with jitter >55 μs exceeding 40% and mean jitter exceeding 55 μs had high sensitivity and specificity in the diagnosis of ALS.
Conclusions:
Single-fiber electromyography can supply valuable information in helping to differentiate ALS from CS.
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