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Updated: May 11, 2026

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
Published on: April 21, 2021
A biodegradable polymersome with pH-tuning on-off membrane based on poly(β-amino ester) for drug delivery
In Ki Jeong1, Guang Hui Gao, Yi Li
1Department of Polymer Science and Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon, Korea.
Abstract:
A nanoscale biodegradable polymersome with pH-tuning on-off membrane is prepared via the self-assembly of poly(β-amino ester)-based amphiphilic copolymers. The pH-sensitive polymersome-like vesicle structure includes two layers that can encapsulate either hydrophobic or hydrophilic therapeutic drugs at physiological pH 7.4. Below a pH of 7.0, the polymersome membrane forms tunnels through which the drug cargo can be rapidly released. The size and morphology of the polymersome are measured by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The pH sensitivity is confirmed by fluorescence spectroscopy. The pH-sensitive drug-delivery polymersome provides a simple and powerful smart carrier for the delivery and controlled release of drugs.
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