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Updated: May 11, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
Population-based data from the Swedish Colon Cancer Registry
K Kodeda1, L Nathanaelsson, B Jung
1Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. karl.kodeda@vgregion.se
This study provides population-based data for colon cancer patients, offering valuable reference points for clinical trial validity. The findings detail survival rates, surgical interventions, and treatment outcomes in a large contemporary cohort.
Area of Science:
- Oncology
- Epidemiology
- Clinical Trials
Background:
- Evaluating clinical trial external validity requires reference population data.
- This study presents data from a large, contemporary, population-based cohort of patients with colon cancer.
Purpose of the Study:
- To provide population-based data for colon cancer patients.
- To serve as reference points for assessing the external validity of clinical trials.
Main Methods:
- Data extracted from the Swedish Colon Cancer Registry (2007-2011).
- Analysis of a national population cohort of nearly 10 million.
- Inclusion of over 99% of diagnosed colon adenocarcinomas.
Main Results:
- 18,889 patients with 19,526 tumors analyzed.
- Median age 74.1 years; 3-year overall survival 62.7%, cancer-specific survival 71.4%.
- 88.0% operated on, 83.8% had tumors resected; emergency surgery associated with poorer outcomes.
Conclusions:
- The presented population-based data serve as high-quality reference points.
- These data are crucial for evaluating the external validity of colon cancer clinical trials.
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