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Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

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CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...

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Related Experiment Video

Updated: May 11, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Cannabis, ischemic stroke, and transient ischemic attack: a case-control study.

Peter Alan Barber¹, Heidi M Pridmore, Venkatesh Krishnamurthy

¹Department of Neurology, Auckland City Hospital, Auckland, New Zealand. a.barber@auckland.ac.nz

|May 23, 2013

Summary

This summary is machine-generated.

Cannabis use is linked to a higher risk of ischemic stroke, particularly when combined with tobacco use. Further research is needed to determine if cannabis alone is an independent risk factor for stroke.

Keywords:

cannabis drug abuse ischemic stroke transient ischemic attack

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Last Updated: May 11, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Published on: August 18, 2020

Transient Middle Cerebral Artery Occlusion Model of Stroke

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

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Published on: August 18, 2015

Area of Science:

Neurology
Cardiovascular Medicine
Toxicology

Background:

Previous studies suggest a link between cannabis use and stroke.
Investigating the relationship between cannabis consumption and cerebrovascular events is crucial.

Purpose of the Study:

To examine the association between cannabis use and ischemic stroke in young to middle-aged adults.
To determine if cannabis use is an independent risk factor for stroke.

Main Methods:

A case-control study comparing ischemic stroke patients (aged 18-55) with a control group.
Urine drug screens were used to detect cannabis use.
Logistic regression analysis was performed, adjusting for potential confounders like age, sex, ethnicity, and tobacco use.

Main Results:

15.6% of ischemic stroke patients tested positive for cannabis, compared to 8.1% in the control group.
Cannabis use was initially associated with an increased risk of ischemic stroke (OR, 2.30).
After adjusting for tobacco use, this association was no longer statistically significant (OR, 1.59).

Conclusions:

The study suggests an association between a lifestyle involving both cannabis and tobacco and ischemic stroke.
The independent role of cannabis in stroke risk, separate from tobacco, requires further investigation.