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Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 11, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

PEpiD: a prostate epigenetic database in mammals.

Jiejun Shi¹, Jian Hu, Qing Zhou

¹Shanghai Key Laboratory of Signaling and Disease Research, Department of Bioinformatics, Shanghai Tenth People's Hospital, The School of Life Sciences and Technology, Tongji University, Shanghai, China.

|May 23, 2013

Summary

The Prostate Epigenetic Database (PEpiD) consolidates DNA methylation, histone modification, and microRNA data for prostate cancer research. This resource aids understanding of epigenetic gene regulation and identifies potential diagnostic and therapeutic targets.

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Last Updated: May 11, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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Published on: May 22, 2018

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Area of Science:

Oncology
Epigenetics
Bioinformatics

Background:

Epigenetic mechanisms significantly influence prostate cancer development and progression by altering gene expression.
Key epigenetic modifications include DNA methylation, histone modification, and microRNA dysregulation.

Purpose of the Study:

To establish the Prostate Epigenetic Database (PEpiD) as a centralized resource for prostate cancer epigenetics.
To facilitate research into the roles of DNA methylation, histone modification, and microRNA in prostate cancer.

Main Methods:

Curated and archived epigenetic data (DNA methylation, histone modification, microRNA) from human, mouse, and rat prostate cancer studies.
Developed a user-friendly interface with distinct visualizations for different epigenetic data types.
Integrated prostate-related ENCODE tracks and transcription factor data.

Main Results:

PEpiD provides comprehensive information including genomic loci, tissue source, experimental methods, and gene expression changes.
Offers graphic views of DNA methylation patterns and CpG islands.
Displays histone modification changes (hyper/hypo) correlated with gene expression alterations (up/down).

Conclusions:

PEpiD serves as a valuable resource for understanding epigenetic mechanisms in prostate cancer.
The database supports research into the diagnostic and prognostic potential of epigenetic aberrations.
Information within PEpiD can guide the development of novel therapeutic strategies for prostate cancer.