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Gastric dysfunction in dialysed patients with chronic renal failure
Agata Furgała1, Urszula Błaut-Kadzielska, Magdalena Stojakowska
1Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland. afurgala@cm-uj.krakow.pl
Folia Medica Cracoviensia
|May 24, 2013
Summary
Patients with chronic renal failure (CRF) exhibit impaired gastric myoelectrical activity and elevated gastrointestinal hormones, contributing to digestive symptoms. This study investigated these issues in patients undergoing hemodialysis (HD) and peritoneal dialysis (CAPD).
Area of Science:
- Nephrology
- Gastroenterology
- Physiology
Background:
- Chronic renal failure (CRF) is associated with disturbances in gastric motor functions.
- Gastrointestinal (GI) symptoms are common in patients with CRF.
Purpose of the Study:
- To investigate the relationship between GI symptoms, gastric myoelectrical activity, and regulatory peptides in CRF patients undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).
Main Methods:
- Gastric myoelectric activity was assessed using electrogastrography (EGG) in 23 CAPD patients, 21 HD patients, and 48 healthy controls.
- GI symptom severity was quantified via a questionnaire.
- Plasma levels of gastrin, motilin, VIP, and CCK were measured.
Main Results:
- CRF patients (CAPD and HD) showed significantly reduced normal gastric wave rhythms compared to controls in both fasting and fed states.
- Abnormal EGG findings were present in 61.3% of CRF patients in the fasting state and 40.9% in the fed state.
- Elevated plasma concentrations of gastrin and CCK were observed in fasted and fed CRF patients, while VIP and motilin were increased in the fed state.
Conclusions:
- Patients with CRF exhibit impaired gastric myoelectrical activity and elevated GI hormone levels.
- Gastric dysmotility and hormonal imbalances appear to be significant contributors to GI symptoms in CRF patients.
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