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Histologic evaluation of intermetatarsal Morton's neuroma
Matrona Giakoumis1, Jay D Ryan, Jigna Jani
1Department of Podiatry, DeKalb Medical Center, Decatur, GA 30033, USA. mgiakoumis@gmail.com
Summary
Histologic findings in Morton's neuromas showed degenerative changes in most cases, but lacked consistent similarities. Patient age and comorbidities like hypertension may influence these changes.
Area of Science:
- Podiatry
- Orthopedic Pathology
- Surgical Pathology
Background:
- Neuromas, particularly Morton's neuroma, present diagnostic challenges in surgical pathology.
- Understanding histologic variations and associated factors is crucial for accurate diagnosis and patient management.
Purpose of the Study:
- To identify consistent histologic similarities among surgically excised Morton's neuromas.
- To investigate correlations between neuroma histology and patient comorbidities.
Main Methods:
- Analysis of 22 surgically excised neuroma specimens with preoperative diagnosis of Morton's neuroma.
- Histologic evaluation performed by a single, specialized pathologist.
Main Results:
- Degenerative changes observed in 59% of specimens.
- Patient age demonstrated trends affecting nerve fibrosis, diameter, vessel obstruction, and degenerative changes.
- Hypertension was the most frequent comorbidity (44%).
Conclusions:
- No significant histologic similarities were consistently found across all neuroma specimens.
- Degenerative changes are a common feature in Morton's neuromas.
- Reproducibility of histologic findings may be influenced by patient age, sex, and comorbidities.
