Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Nucleosome Remodeling

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cell identity and 5-hydroxymethylcytosine.

Epigenetics & chromatin·2025

Same author

A dynamic histone-based chromatin regulatory toolkit underpins genome and developmental evolution in an invertebrate clade.

Genome biology·2025

Same author

Chuanxiong-Danggui herb pair alleviated cognitive deficits of APP/PS1 mice by promoting mitophagy.

Journal of ethnopharmacology·2025

Same author

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation.

BMC biology·2025

Same author

Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing.

Communications biology·2025

Same author

Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria.

Genome biology·2024

Search research articles

Related Experiment Video

Updated: May 11, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Epigenetic mechanisms in development and disease.

Adele Murrell¹, Paul J Hurd, Ian C Wood

¹Epigenetics and Imprinting Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

Biochemical Society Transactions

|May 24, 2013

Summary

Epigenetic mechanisms, including DNA methylation and histone modifications, are crucial for development and disease. Ongoing research explores new epigenetic modifications and their regulatory roles in gene expression.

More Related Videos

Methylated DNA Immunoprecipitation

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Related Experiment Videos

Last Updated: May 11, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Methylated DNA Immunoprecipitation

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Technological advancements enable DNA sequencing, revealing genetic differences between individuals and within cells.
Understanding epigenetic mechanisms is key to individuality and disease, yet much remains unknown.
The 80th Biochemical Society Annual Symposium focused on Epigenetic Mechanisms in Development and Disease.

Purpose of the Study:

To discuss the latest insights into epigenetic mechanisms from leading researchers.
To highlight the significance of DNA methylation and histone modifications in development and disease.
To explore emerging epigenetic modifications and their functional roles.

Main Methods:

Review of recent research presented at the symposium.
Discussion of DNA methylation and its role in development, imprinting, and diseases like cancer.
Exploration of methylcytosine to hydoxymethylcytosine conversion and its implications.
Analysis of post-translational modifications on histone proteins and their gene regulatory functions.

Main Results:

DNA methylation is a well-studied epigenetic mechanism with implications in development and cancer.
The discovery of hydoxymethylcytosine opens new avenues for epigenetic research.
Histone modifications play a significant role in regulating gene expression, with new variations continually being identified.
Understanding the protein complexes responsible for adding/removing histone modifications is advancing.

Conclusions:

Epigenetic mechanisms, including DNA methylation and histone modifications, are fundamental to development and disease.
Emerging epigenetic modifications like hydoxymethylcytosine require further investigation.
Continued research into the complexes and interactions governing epigenetic modifications promises future breakthroughs.