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Updated: May 11, 2026

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
Published on: November 23, 2012
Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents
Rodrigo E Mendes1, Lalitagauri M Deshpande, Jihye Kim
1JMI Laboratories, North Liberty, Iowa, USA. rodrigo-mendes@jmilabs.com
Abstract:
This study describes a clinical case of a 71-year-old male with a history of ischemic cardiomyopathy after left ventricular assist device (LVAD) endocarditis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) and a rare linezolid-resistant Streptococcus sanguinis strain (MIC, 32 μg/ml). The patient received courses of several antimicrobial agents, including linezolid for 79 days. The S. sanguinis strain had mutations in the 23S rRNA (T2211C, T2406C, G2576T, C2610T) and an amino acid substitution (N56D) in L22 and exhibited cross-resistance to ribosome-targeting agents.
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