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Melatonin-based therapeutics for neuroprotection in stroke
Kazutaka Shinozuka1, Meaghan Staples, Cesar V Borlongan
1Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. cborlong@health.usf.edu.
International Journal of Molecular Sciences
|May 24, 2013
Summary
This review highlights melatonin
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Stroke is a leading cause of death and disability worldwide.
- Current treatments for stroke are limited in efficacy.
- Melatonin, a hormone with antioxidant and anti-inflammatory properties, shows promise for neuroprotection.
Purpose of the Study:
- To review the evidence for melatonin's neuroprotective effects in stroke.
- To explore the role of melatonin receptors in stroke pathophysiology and treatment.
- To discuss the translational potential of melatonin-based therapies for stroke.
Main Methods:
- Literature review of preclinical and clinical studies on melatonin and stroke.
- Analysis of mechanisms underlying melatonin's neuroprotective actions.
- Evaluation of stem cell therapy's role in stroke, focusing on melatonin secretion.
Main Results:
- Exogenous melatonin treatment demonstrates neuroprotective effects in laboratory stroke models.
- Transplantation of melatonin-secreting cells shows therapeutic benefits in stroke.
- A novel mechanism involving melatonin receptors in stem cell therapy for stroke is identified.
Conclusions:
- Melatonin and targeting melatonin receptors represent a promising neuroprotective strategy for stroke.
- Further translational research is needed to optimize melatonin-based treatments for human stroke patients.
- Melatonin-based therapeutics hold potential for improving stroke outcomes.
