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Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Role of cardiotrophin-1 in obesity and insulin resistance
María J Moreno-Aliaga1, M Asunción Romero-Lozano, David Castaño
1Department of Nutrition, Food Sciences, Physiology and Toxicology; University of Navarra; Pamplona, Spain.
Abstract:
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. In a recent study we examined the metabolic features of ct-1 null mice and the effects on body composition, glucose and lipid metabolism of acute and chronic administration of recombinant CT-1. Our data revealed that CT-1 is a key regulator of energy metabolism with potential applications in the treatment of obesity and the metabolic syndrome. This commentary discusses the significance of these findings in the context of other key studies in the field of obesity and insulin resistance.
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