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The liver: Key in regulating appetite and body weight
Barbara C Fam1, Christos N Joannides, Sofianos Andrikopoulos
1Department of Medicine (Austin Health); University of Melbourne; Heidelberg, VIC Australia.
Adipocyte
|May 24, 2013
Summary
Liver fructose-1,6-bisphosphatase (FBPase) regulates appetite and body weight. Overexpressing FBPase in mice reduced weight and adiposity by decreasing food intake, highlighting the liver
Area of Science:
- Metabolic regulation
- Obesity research
- Hepatology
Background:
- Liver fructose-1,6-bisphosphatase (FBPase) is implicated in glucose metabolism and elevated in obesity.
- The broader metabolic roles of FBPase beyond glucose regulation are not fully understood.
Purpose of the Study:
- To investigate the role of liver FBPase in regulating body weight and adiposity.
- To explore the mechanisms by which FBPase influences energy balance.
Main Methods:
- Generated transgenic mice overexpressing liver FBPase.
- Conducted comprehensive physiological and biochemical assessments of energy balance.
- Utilized intervention studies to block FBPase activity.
Main Results:
- FBPase transgenic mice exhibited reduced body weight (10%), adiposity (50%), and food intake (15%) without altered energy expenditure.
- Elevated leptin and cholecystokinin, increased fatty acid oxidation, and reduced appetite-stimulating neuropeptides (NPY, AGRP) were observed.
- Blocking FBPase activity normalized food intake and body weight.
Conclusions:
- Liver FBPase is a novel regulator of appetite and adiposity.
- The liver plays a significant role in the regulation of body weight and energy homeostasis.
- Targeting liver FBPase may offer therapeutic strategies for obesity.
Keywords:
3-beta-hydroxybutyrateCCKFBPase transgenic miceNZO mouseadiposityappetitebody weight regulationleptinlivervagus nerveMore Related Videos
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