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Related Experiment Videos

Genetic control of avian scleroderma.

H Abplanalp1, M E Gershwin, E Johnston

  • 1Department of Avian Sciences, University of California, Davis 95616.

Immunogenetics
|January 1, 1990
PubMed
Summary

Avian scleroderma inheritance was studied in chickens. Genetic analysis revealed that specific genes, particularly within the major histocompatibility complex, influence the disease

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Area of Science:

  • Immunogenetics
  • Animal Genetics
  • Avian Pathology

Background:

  • Avian scleroderma is a fibrotic autoimmune disease in chickens.
  • It shares similarities with human scleroderma, making it a valuable model.
  • Understanding its inheritance is crucial for disease management.

Purpose of the Study:

  • To investigate the genetic basis of avian scleroderma inheritance.
  • To identify genetic factors influencing disease penetrance.
  • To explore the role of the major histocompatibility complex in disease susceptibility.

Main Methods:

  • Crossbreeding experiments between a disease-prone chicken line (line 200) and eight partially inbred lines.
  • Phenotypic assessment of comb inflammation and lesions in 4-week-old chickens.
  • Genotyping of backcross generations for major histocompatibility complex haplotypes.

Main Results:

  • Line 200 chickens exhibited high disease incidence, while F1 crosses were normal.
  • Backcrosses showed variable disease incidence, indicating modifying genes.
  • Major histocompatibility complex heterozygotes (e.g., B3B, B14B, B15B) displayed lower scleroderma penetrance compared to line 200 homozygotes (BsBs).

Conclusions:

  • Avian scleroderma is influenced by multiple genes, including major histocompatibility complex-linked factors.
  • Genes within the major histocompatibility complex can modify the penetrance of the primary disease-causing genes.
  • Genetic diversity, particularly related to MHC haplotypes, plays a role in disease resistance.

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