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Updated: May 11, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
[Influence of chosen metals on the citric acid cycle]
Ewa Rojczyk-Gołebiewska1, Marek Kucharzewski
1Departament of Histology and Embriology, Medical University of Silesia, Katowice, Poland. ewarojczyk@gmail.com
Abstract:
Industrial activity growth influenced not only technological progress, but also had negative effects on human natural environment. It results among others in increased human exposition to heavy metals. In case of detoxication mechanisms disturbance in organism, heavy metals cumulate in tissues causing mutations and disrupting metabolism, including Krebs cycle. Recent studies have revealed that iron, zinc and manganese have especially strong influence on Krebs cycle. These elements act as cofactors or inhibitors regulating activity of particular enzymes of this cycle, which has a reflection in cellular energy production disturbances.
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