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Hepcidin and iron metabolism disorders in patients with chronic kidney disease

Marija Jelić1, Tatjana Cvetković, Vidojko Djordjević

  • 1Clinical Biochemical Laboratory, Military Hospital Nis, Nis, Serbia. jelicmarija1211@gmail.com

Vojnosanitetski Pregled
|May 25, 2013
PubMed

Insights

Hepcidin levels correlate with iron metabolism in chronic kidney disease (CKD) patients. This finding suggests hepcidin can help diagnose and monitor iron disorders in CKD.

Area of Science:

  • Nephrology
  • Hematology
  • Biochemistry

Background:

  • Hepcidin is implicated in iron metabolism disorders.
  • Chronic kidney disease (CKD) affects iron homeostasis.
  • Understanding hepcidin's role in CKD is crucial.

Purpose of the Study:

  • To investigate the relationship between hepcidin concentration and iron metabolism parameters in CKD patients.
  • To compare hepcidin levels across different stages of CKD.

Main Methods:

  • 104 CKD patients (64 hemodialysis, 40 pre-dialysis) were studied.
  • Patients received erythropoietin and iron supplementation.
  • Iron status, anemia parameters, inflammation, and hepcidin levels were assessed, with hemodialysis patients stratified by ferritin levels.

Main Results:

  • Hemodialysis patients exhibited lower red blood cell counts, hemoglobin, and transferrin saturation, but higher iron, ferritin, and hepcidin.
  • Lower serum ferritin subgroups (<199 ng/mL) showed reduced inflammation markers (hsCRP) and improved iron status indicators.
  • Hepcidin levels strongly correlated with serum ferritin, peaking in the lowest and highest ferritin groups.

Conclusions:

  • Hepcidin may serve as a valuable biomarker for diagnosing and monitoring anemia and iron metabolism disturbances in CKD patients.
  • Further research can elucidate hepcidin's precise role in CKD pathophysiology.
Abstract

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