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PXR cross-talks with internal and external signals in physiological and pathophysiological responses
Susumu Kodama1, Masahiko Negishi
1Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-Ku, Sendai , Japan. kodama@m.tohoku.ac.jp
Drug Metabolism Reviews
|May 25, 2013
Summary
Pregnane X receptor (PXR) senses external and internal signals to regulate metabolism and immunity. Understanding PXR
Area of Science:
- Molecular biology
- Pharmacology
- Immunology
Background:
- Pregnane X receptor (PXR) is a key xeno-sensing transcription factor.
- PXR regulates genes involved in xenobiotic metabolism and transport.
- Emerging evidence shows PXR responds to internal signals, impacting immune responses.
Purpose of the Study:
- To review recent advancements in understanding PXR's physiological and pathophysiological roles.
- To elucidate PXR's implications in human diseases and drug therapy.
- To explore the molecular mechanisms of PXR-mediated gene regulation.
Main Methods:
- Literature review of recent scientific progress on PXR.
- Analysis of PXR's role in response to external and internal stimuli.
- Elucidation of molecular mechanisms underlying PXR's gene regulation.
Main Results:
- PXR acts as a sensor for both xenobiotics and endogenous signals.
- PXR modulates metabolic pathways and cellular signaling in response to these signals.
- PXR plays a dual role, offering therapeutic potential but also posing health risks.
Conclusions:
- PXR is a critical regulator of homeostasis, adapting the body to internal and external challenges.
- PXR is a promising therapeutic target for metabolic and inflammatory diseases.
- Further research into PXR mechanisms is crucial for optimizing its therapeutic applications and mitigating adverse effects.
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