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Related Experiment Video

Updated: May 11, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Induction therapy in lung transplantation.

Stuart C Sweet1

  • 1Pediatric Lung Transplant Program, Washington University School of Medicine, St. Louis, MO, USA. sweet@wustl.edu

Transplant International : Official Journal of the European Society for Organ Transplantation
|May 25, 2013
PubMed
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Lung transplant induction strategies, using T-cell depleting agents and IL-2 Receptor antagonists, show some benefits against acute rejection. Long-term advantages require further investigation, with future research focusing on tolerogenic approaches.

Area of Science:

  • Immunosuppression strategies in solid organ transplantation.
  • Lung transplantation protocols and outcomes.

Background:

  • Current lung transplant induction therapies often mirror those in other solid organ transplants.
  • Commonly used agents include polyclonal (e.g., Atgam, RATG) and monoclonal (e.g., OKT3) T-cell depleting antibodies, and IL-2 Receptor antagonists (basiliximab, daclizumab).

Purpose of the Study:

  • To review current induction strategies in lung transplant recipients.
  • To evaluate the evidence for the efficacy of induction therapy in lung transplantation, particularly regarding acute rejection and long-term outcomes.
  • To explore future directions in lung transplant induction, including tolerogenic approaches.

Main Methods:

  • Review of existing literature and registry data, including International Society for Heart and Lung Transplantation (ISHLT) reports.

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Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
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Last Updated: May 11, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
09:34

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation

Published on: October 31, 2025

  • Analysis of the use and effectiveness of T-cell depleting agents and IL-2 Receptor antagonists.
  • Discussion of emerging tolerogenic strategies.

    • Main Results:

    • Induction therapy in lung transplantation is associated with reduced acute rejection rates.
    • Registry data suggest a small benefit in freedom from bronchiolitis obliterans and improved long-term survival.
    • Evidence regarding the long-term benefits of current induction strategies has been less convincing in some studies.

    Conclusions:

    • While current induction strategies offer benefits in managing acute rejection post-lung transplant, their long-term impact requires further validation.
    • Future research should explore novel tolerogenic approaches, drawing parallels with advancements in renal transplantation, to enhance long-term outcomes and graft survival.