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Altered angiogenesis in low birth weight individuals: a role for anti-angiogenic circulating factors

Isabelle Ligi1, Stéphanie Simoncini, Edwige Tellier

  • 1Department of Neonatology, La Conception Hospital , Marseille , France .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 25, 2013
PubMed

Insights

Low birth weight babies exhibit impaired endothelial progenitor cell function due to antiangiogenic factors in their serum, potentially impacting future cardiovascular health.

Area of Science:

  • Neonatal research
  • Vascular biology
  • Cardiovascular health

Background:

  • Low birth weight (LBW) is a known risk factor for adult hypertension.
  • Endothelial progenitor cells (EPCs) show dysfunction in LBW neonates.
  • Investigating angiogenic factors in LBW neonates is crucial.

Purpose of the Study:

  • To determine if plasma pro- or anti-angiogenic factors are linked to EPC dysfunction in LBW neonates.
  • To explore the association between these factors and impaired angiogenesis.

Main Methods:

  • Umbilical cord blood was collected from normal and LBW neonates.
  • Endothelial colony-forming cells (ECFCs) from controls were cultured with serum from both groups.

Main Results:

  • LBW serum significantly reduced ECFC proliferation and migration.
  • VEGF levels were lower, while sVEGFR and PF4 were higher in LBW neonates.
  • Adding VEGF reversed the inhibitory effects of LBW serum on ECFCs.

Conclusions:

  • LBW infant serum contains antiangiogenic factors affecting ECFCs.
  • The VEGF/sVEGF/PF4 pathway is implicated in LBW-associated EPC dysfunction.
Abstract

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