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Updated: May 11, 2026

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The role of interleukin-17A in colorectal tumorigenesis
Yingpeng Shi1, Hui Lin, Jing Cui
1Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Abstract:
It has been well documented that interleukin (IL)-17A mainly produced by the newly identified T cell subtype Th17 cells is an important proinflammatory cytokine that plays a vital pathogenic role in the process of human inflammatory bowel diseases. Recently, new information concerning the biological activities of IL-17A relating to the development of colorectal cancer (CRC) has also been reported. The present mini-review focuses on recent observations concerning the role of IL-17A in the development of CRCs, and it discusses the clinical significance of IL-17A as a biomarker and potential therapeutic target.
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