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The relationship between vitamin D and PTH levels and cardiovascular risk in the elderly hypertensives

Sena Memnune Ulu1, Alper Ulaslı, Fatima Yaman

  • 1Department of Internal Medicine and Nephrology .

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|May 25, 2013
PubMed

Insights

Hypertension in older adults is linked to vitamin D deficiency and high parathyroid hormone levels, both increasing cardiovascular risk. Early treatment of hypertension and vitamin D deficiency is recommended for this age group.

Area of Science:

  • Endocrinology
  • Cardiology
  • Geriatrics

Background:

  • Vitamin D deficiency and elevated parathyroid hormone (PTH) are increasingly recognized as potential contributors to cardiovascular risk.
  • Hypertension is a major risk factor for cardiovascular disease, particularly in the elderly population.

Purpose of the Study:

  • To investigate the relationship between vitamin D, parathyroid hormone (PTH), and cardiovascular risk (CVR) in hypertensive patients aged 65 and over.
  • To compare CVR, blood pressure stages, and vitamin D/PTH levels between hypertensive patients and normotensive controls.

Main Methods:

  • Study included 84 hypertensive patients and 68 normotensive controls.
  • Levels of 25-(OH) vitamin D and PTH were measured.
  • Cardiovascular risk degrees and blood pressure stages were assessed and compared with vitamin D and PTH levels.

Main Results:

  • Patients with vitamin D deficiency (VDD) had significantly higher systolic and diastolic blood pressure (BP) than those without VDD (p<0.001).
  • Patients with hyperparathyroidism exhibited significantly higher systolic and diastolic BP compared to those without (p=0.012, p=0.036).
  • Cardiovascular risk (CVR) showed a significant inverse correlation with vitamin D levels (r=-0.752, p<0.001) but not with hyperparathyroidism (r=0.210, p=0.055).

Conclusions:

  • Hypertension in older adults is associated with vitamin D deficiency (VDD).
  • The stage of hypertension contributes to vitamin D insufficiency, hyperparathyroidism, and elevated cardiovascular risk.
  • Clinicians should consider aggressive management of hypertension and VDD in patients over 65.
Abstract

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