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Related Concept Videos

Composition of Blood Plasma01:24

Composition of Blood Plasma

Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins, binding to...

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Related Experiment Video

Updated: May 11, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

Blood plasma reference material: a global resource for proteomic research.

Johan Malm1, Pia Danmyr, Rolf Nilsson

  • 1Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skåne University Hospital, 20502 Malmö, Sweden.

Journal of Proteome Research
|May 25, 2013
PubMed
Summary

A new heparinized blood plasma standard is introduced for the global proteomics community. This resource aids quantitative proteomic studies and disease research, supporting initiatives like the Chromosome Human Proteome Project.

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A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation
07:12

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

Related Experiment Videos

Last Updated: May 11, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation
07:12

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Proteomics

Background:

  • Growing demand for clinical and blood samples in research, particularly in translational research (proteomics, genomics, metabolomics).
  • Blood samples are the most common biological samples globally, utilized across various life science applications.

Purpose of the Study:

  • To introduce a novel reference blood plasma standard (heparin) as a global resource for the proteomics community.
  • To support quantitative proteomic studies and global initiatives like the Chromosome Human Proteome Project (C-HPP).

Main Methods:

  • Development of reference plasma standards using defined control (<3 mg/L C-reactive protein) and disease (>30 mg/L C-reactive protein) groups.
  • Inclusion of diverse age groups: newborns (1-2 weeks), youngsters (15-30 years), middle-aged (30-50 years), and elderly (65+ years).
  • Pooling of 80 patients per group to create reference plasma pools.

Main Results:

  • Characterization data provided for the developed reference blood plasma standards.
  • Successful evaluation through pilot sample processing in biobanking operations.
  • The standards are now available as a resource for quantitative proteomic studies.

Conclusions:

  • The new reference plasma standards serve as a valuable global resource for proteomics research.
  • High-quality reference samples will benefit large-scale projects aiming to map the human proteome and link it to diseases.
  • These standards facilitate advancements in understanding human diseases through proteomic analysis.