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Published on: October 12, 2017

Lipoprotein(a) concentrations in adult congenital heart disease patients

Efrén Martínez-Quintana1, Fayna Rodríguez-González

  • 1Cardiology Service, Insular-Materno Infantil University Hospital, Las Palmas de Gran Canaria, Spain.

Congenital Heart Disease
|May 25, 2013
PubMed

Insights

Adult congenital heart disease patients do not show significantly different Lipoprotein(a) levels compared to controls. However, they exhibit lower total and LDL cholesterol, with a positive correlation between LDL cholesterol and Lipoprotein(a).

Area of Science:

  • Cardiology
  • Biochemistry
  • Genetics

Background:

  • Lipoprotein(a) (Lp(a)) is implicated in atherosclerosis, inflammation, and thrombosis.
  • Understanding Lp(a) in adult congenital heart disease (ACHD) is crucial for risk assessment.

Purpose of the Study:

  • To compare serum Lp(a) concentrations in ACHD patients versus controls.
  • To investigate factors influencing Lp(a) levels in ACHD, including cholesterol, CRP, and N-terminal-pro-B-type natriuretic peptide.

Main Methods:

  • Serum Lp(a), total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and C-reactive protein (CRP) were measured in 117 ACHD patients and 152 controls.
  • N-terminal-pro-B-type natriuretic peptide levels were determined in ACHD patients.
  • Multivariate logistic regression and Pearson's correlation analyses were employed.

Main Results:

  • No significant difference in Lp(a) concentrations (>30 mg/dL) was observed between ACHD patients and controls after multivariate analysis.
  • ACHD patients had lower total cholesterol and LDL cholesterol compared to controls.
  • A significant positive correlation was found between LDL cholesterol and Lp(a) concentrations (r=0.27, P=.004) in ACHD patients.

Conclusions:

  • ACHD patients do not exhibit altered Lp(a) levels compared to the general population.
  • Lower total and LDL cholesterol levels are characteristic of ACHD patients.
  • The positive correlation between LDL cholesterol and Lp(a) suggests a potential shared pathway or risk factor in ACHD.
Abstract

Keywords:
C-reactive ProteinCongenital Heart DiseaseLipidLipoprotein(a)

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