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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2012
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Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests.

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Related Experiment Video

Updated: May 11, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

[Atopic dermatitis and allergy].

C Karila1

  • 1Service de pneumologie et allergologie pédiatriques, hôpital Necker-Enfants Malades, université Paris V - Descartes, 149, rue de Sèvres, 75015 Paris, France. chantal.karila@nck.aphp.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Identifying allergies is crucial for managing atopic dermatitis (AD). Early diagnosis of food allergies in infants and aeroallergen testing in older children can guide treatment, including immunotherapy, for better control of this common skin condition.

Keywords:
Aero allergyAllergie alimentaireAllergie respiratoireAtopic dermatitisDermatite atopiqueFood allergy

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Last Updated: May 11, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Area of Science:

  • Dermatology
  • Allergology
  • Pediatrics

Context:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition in childhood.
  • It often represents the initial manifestation of the atopic march.
  • Identifying triggers like food or respiratory allergies is essential for effective management.

Purpose:

  • To explore the diagnostic challenges and therapeutic implications of food and aeroallergen allergies in atopic dermatitis.
  • To differentiate between sensitization and clinical relevance of allergens in AD.
  • To guide clinical practice in managing pediatric atopic dermatitis.

Summary:

  • In infants, severe, early-onset AD unresponsive to topical corticosteroids and associated with immediate reactions may suggest food allergy, though allergen sensitization is common and clinical significance requires expert evaluation.
  • For older children, aeroallergen exposure can exacerbate AD, making allergy testing valuable for selecting specific immunotherapy.
  • Consulting an allergist is recommended to avoid unnecessary elimination diets and to confirm allergen involvement.

Impact:

  • Improved diagnostic accuracy for allergy-related atopic dermatitis.
  • Personalized treatment strategies, including immunotherapy, for better disease control.
  • Reduced reliance on ineffective elimination diets, improving patient quality of life.