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Updated: May 11, 2026

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4⁺ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Human immunodeficiency virus-associated obstructive lung diseases.

Matthew R Gingo¹, Alison Morris, Kristina Crothers

¹Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Clinics in Chest Medicine

|May 25, 2013

Summary

This summary is machine-generated.

People with human immunodeficiency virus (HIV) are more prone to chronic obstructive pulmonary disease (COPD). Poorly controlled HIV and lower CD4 counts worsen lung function, increasing COPD risk.

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Area of Science:

Pulmonary Medicine
Infectious Diseases
HIV Research

Background:

Antiretroviral therapy (ART) has improved human immunodeficiency virus (HIV) management.
Epidemiologic studies indicate a higher prevalence of chronic obstructive pulmonary disease (COPD) in persons with HIV compared to HIV-uninfected individuals.

Purpose of the Study:

To review the evidence linking HIV infection to obstructive lung disease.
To discuss the management of obstructive lung disease in HIV-infected patients.

Main Methods:

Review of existing epidemiologic studies and clinical evidence.
Analysis of factors influencing lung function in HIV-infected individuals.

Main Results:

HIV-infected individuals exhibit increased prevalence and incidence of COPD.
Poor viral control or lower CD4 cell counts in HIV-infected persons correlate with more airflow obstruction, accelerated lung function decline, and potentially impaired diffusion.

Conclusions:

HIV infection is linked to an increased risk of obstructive lung disease.
Management strategies for COPD in HIV-infected patients require careful consideration of HIV disease control and immune status.