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Related Experiment Video

Updated: May 11, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Significant sleep disturbances in euthymic bipolar patients.

Paulo Marcos Brasil Rocha1, Fernando Silva Neves, Humberto Corrêa

  • 1Programa de Pós-graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (MG), Brazil.

Comprehensive Psychiatry
|May 25, 2013
PubMed
Summary

Bipolar disorder (BD) patients in an euthymic phase show significantly poorer sleep quality compared to healthy individuals. This includes issues with sleep latency and efficiency, highlighting sleep disturbances even outside major mood episodes.

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Area of Science:

  • Psychiatry
  • Sleep Medicine
  • Neuroscience

Background:

  • Sleep dysfunction is common in bipolar disorder (BD), even during euthymic periods.
  • Understanding sleep status in euthymic BD patients is crucial for comprehensive care.

Purpose of the Study:

  • To compare sleep quality between euthymic bipolar disorder patients and healthy controls.
  • To identify specific sleep disturbances in BD patients during remission.

Main Methods:

  • A case-control study involving 105 euthymic BD patients and 104 healthy controls.
  • Sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI).
  • Euthymia confirmed by Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) scores.

Main Results:

  • 82.9% of euthymic BD patients reported poor sleep quality versus 21.2% in controls (p=0.000).
  • BD patients exhibited significantly longer sleep latency (p=0.000) and poorer sleep efficiency (p=0.000).
  • Sleep duration was comparable between groups (p=0.535).

Conclusions:

  • Euthymic BD patients demonstrate significantly worse overall sleep quality compared to healthy controls.
  • Specific sleep disruptions in latency and efficiency persist even when mood symptoms are absent.
  • The PSQI is a valuable tool for assessing sleep disturbances in BD patients.