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Updated: May 11, 2026

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers
Bernard Amaraesekera1, Phillip D Marchis, Krzysztof P Bobinski
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Abstract:
A robust, modular, semi-automated synthesis unit useful for conducting radiochemical reactions under pressurized conditions (up to ∼200psi [1.4MPa]) for the production of PET biomarkers has been developed. This compact unit (7.6cm×33.0cm×58.4cm) is capable of performing any single step reaction that is generally encountered in radiochemical syntheses, and multiple units can be combined for more complex syntheses. The versatility of a 3-unit system is exemplified by reliably conducting the multi-step syntheses of 2'-deoxy-2'-[(18)F]fluoro-1-β-arabinofuranosyl-uracil and -cytosine derivatives, which involve corrosive and moisture sensitive reagents under pressurized conditions.
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