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Related Experiment Video

Updated: May 11, 2026

Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Plug-and-play modules for flexible radiosynthesis.

Henry Herman¹, Graciela Flores, Kevin Quinn

¹Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine

|May 25, 2013

Summary

This summary is machine-generated.

A novel plug-and-play radiosynthesis platform offers flexible, modular configurations for diverse radiolabeling protocols. This automated system enhances radiosynthesis efficiency and versatility for various applications.

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Last Updated: May 11, 2026

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Published on: February 12, 2021

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Area of Science:

Radiochemistry
Nuclear Medicine
Chemical Engineering

Background:

Radiosynthesis is crucial for producing radiotracers used in medical imaging.
Current radiosynthesis platforms can be inflexible and require complex setups.
There is a need for adaptable and user-friendly radiosynthesis systems.

Purpose of the Study:

To develop and validate a versatile, modular, plug-and-play radiosynthesis platform.
To demonstrate the system's capability to handle diverse radiosynthesis protocols.
To enable semi-automated control of radiosynthesis through a unified software interface.

Main Methods:

Designed modular subunits for reagent storage/delivery, evaporations/sealed reactions, and purification.
Incorporated a robotic mechanism in the reaction module for high-pressure compatibility.
Connected modules using fluidic connections and controlled the system via software.

Main Results:

Successfully performed radiosyntheses of 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG), 1-[(18)F]fluoro-4-nitrobenzene ([(18)F]FNB), and 2'-deoxy-2'-[(18)F]fluoro-1-β-d-arabinofuranosyl cytosine (d-[(18)F]FAC).
Demonstrated the platform's flexibility in handling different solvents and temperatures due to high-pressure capabilities.
Validated the system's ease of configuration and semi-automated control.

Conclusions:

The developed plug-and-play platform provides a flexible and versatile solution for radiosynthesis.
The modular design and software control facilitate diverse radiotracer production.
This system has the potential to streamline radiosynthesis workflows in research and clinical settings.