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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

The inflammatory tissue microenvironment in IBD.

Sean P Colgan1, Valerie F Curtis, Eric L Campbell

  • 1Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA. sean.colgan@UCDenver.edu

Inflammatory Bowel Diseases
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel diseases (IBD) involve gut microenvironments with metabolic shifts and hypoxia. Targeting these metabolic pathways offers potential therapeutic strategies for IBD patients.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Metabolic research

Background:

  • Inflammatory bowel diseases (IBD) arise from innate immune responses in genetically susceptible individuals.
  • The intestinal microenvironment significantly influences IBD progression and resolution.
  • Intestinal compartmentalization leads to metabolic shifts within tissue microenvironments.

Purpose of the Study:

  • To review the current understanding of metabolic microenvironments in IBD.
  • To discuss the potential of targeting these microenvironmental changes for IBD therapy.

Main Methods:

  • Literature review of current research on IBD metabolic microenvironments.
  • Analysis of metabolic shifts, hypoxia, and therapeutic targeting strategies.

Main Results:

  • Active IBD involves metabolic stress and hypoxia due to high demands exceeding supply.
  • Microenvironmental cues play a crucial role in disease dynamics.
  • Targeting metabolic pathways presents both opportunities and challenges for IBD treatment.

Conclusions:

  • Understanding intestinal metabolic microenvironments is key to IBD management.
  • Therapeutic strategies targeting metabolic pathways in IBD require careful consideration of benefits and drawbacks.