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Updated: May 11, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Immunology of age-related macular degeneration
Jayakrishna Ambati1, John P Atkinson, Bradley D Gelfand
1Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA. jamba2@email.uky.edu
Abstract:
Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.
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