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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Published on: November 2, 2013

ERG expression and prostatic adenocarcinoma.

Montse Verdu1, Isabel Trias, Ruth Roman

  • 1BIOPAT, Biopatologia Molecular, Grup Assistencia, Avda. Diagonal 660, Planta -1, 08034 Barcelona, Spain. mverdu@histopat.es

Virchows Archiv : an International Journal of Pathology
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

ERG gene rearrangement is a specific alteration in prostate cancer. Immunohistochemical ERG evaluation shows high specificity for prostate carcinomas, aiding in routine pathology diagnostics.

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • ERG gene rearrangement is a specific biomarker in 40-50% of prostate carcinomas.
  • Standardized immunohistochemical assays for ERG have significant diagnostic potential.

Purpose of the Study:

  • To determine the incidence of ERG rearrangement in a Spanish population.
  • To validate the specificity of ERG immunohistochemical evaluation for prostate carcinomas.

Main Methods:

  • Construction of prostate tissue microarrays from radical prostatectomy specimens.
  • Analysis of 160 prostate carcinomas, 26 prostatic hyperplasia, and 10 high-grade prostatic intraepithelial neoplasia samples.
  • Testing of 270 tissue microarrays from common malignant tumors (breast, colon, lung, bladder) using immunohistochemistry.

Main Results:

  • ERG expression was detected in 49% (75/154) of prostate carcinomas, with 52/75 showing strong staining.
  • No ERG expression was observed in high-grade prostatic intraepithelial neoplasia or other tested tumors, except for one focal, weak bladder cancer case.
  • ERG expression was independent of Gleason score, local invasion, and lymph node involvement.

Conclusions:

  • The frequency of ERG detection in the Spanish population aligns with other Caucasian cohorts.
  • Strong ERG protein expression is exclusively found in prostate carcinomas, confirming ERG rearrangement specificity.
  • Immunohistochemical detection of ERG is a valuable tool for routine pathology practice.