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Updated: May 11, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Collagen cross-linking and corneal infections
Joanne B Tayapad1, Aileen Q Viguilla, Johann M G Reyes
1Medical Arts Tower, The Medical City, Pasig City, Philippines.
Current Opinion in Ophthalmology
|May 25, 2013
Summary
Collagen cross-linking shows promise for managing infectious keratitis, offering a potential new treatment beyond antibiotics. Further research is needed to confirm its effectiveness against aggressive corneal infections.
Area of Science:
- Ophthalmology
- Microbiology
- Biomaterials Science
Background:
- Infectious keratitis, a leading cause of blindness, can progress to corneal melt despite antimicrobial therapy.
- Aggressive pathogens and rising antibiotic resistance necessitate novel treatment strategies for corneal infections.
Purpose of the Study:
- To review current data on collagen cross-linking for managing corneal infections.
- To explore collagen cross-linking as an alternative or adjunct therapy for infectious keratitis.
Main Methods:
- Review of recent literature on collagen cross-linking applications in ophthalmology.
- Analysis of studies demonstrating the efficacy of cross-linking in infectious keratitis models.
Main Results:
- Collagen cross-linking strengthens the cornea and has shown effectiveness in treating infectious keratitis.
- The procedure may provide a direct microbiologic cure and inhibit enzymatic degradation by pathogens.
Conclusions:
- Corneal collagen cross-linking presents a promising therapeutic option for infectious keratitis.
- Larger randomized controlled trials are required to validate these findings against standard antibiotic treatments.
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