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Correlation among the heart rate variability indices in healthy children and those with atrial septal defect
Bülent Koca1, Süleyman Bakari, Funda Oztunç
1Department of Pediatric Cardiology, Harran University, Şanlıurfa, Turkey. bkoca78@yahoo.com
Insights
Time and frequency domain measures of heart rate variability (HRV) are correlated in healthy children and those with atrial septal defect (ASD). Some HRV indices are strongly correlated, suggesting they can be used interchangeably.
Area of Science:
- Cardiology
- Pediatric Medicine
- Biomedical Engineering
Background:
- Heart rate variability (HRV) is assessed using time and frequency domain analyses.
- Current research often employs either time or frequency domain measures exclusively.
- Understanding the correlation between these domains is crucial for comprehensive HRV assessment.
Purpose of the Study:
- To investigate the correlation between time and frequency domain indices of HRV.
- To compare HRV correlations in healthy children versus children with atrial septal defect (ASD).
Main Methods:
- Analysis of 24-hour Holter ECG records from 60 children (32 healthy, 28 with ASD).
- Calculation of time domain and frequency domain HRV measures.
- Statistical computation of correlations within and between time and frequency domains.
Main Results:
- A positive correlation was observed across most HRV measures.
- The low-frequency (LF) to high-frequency (HF) ratio showed a negative correlation.
- Correlation strength varied among different HRV indices.
Conclusions:
- Time and frequency domain HRV measures are significantly correlated in both healthy children and ASD patients.
- Certain HRV indices exhibit strong correlations, indicating potential interchangeability in clinical use.
Objectives:
Most researchers use the time domain and spectral analysis in the assessment of heart rate variability (HRV), while others use either the time or frequency domain measures. In this study, we investigated the presence of correlation between the time and frequency domain indices of HRV in normal healthy children and in patients with atrial septal defect (ASD).
Study Design:
A total of 60 children, 28 with ASD and 32 healthy children, were recruited. Time domain measures and frequency domain measures were analyzed from the 24-hour Holter ECG records. Correlation between time domain measures and frequency domain measures as well as correlation within the time domain measures was computed in each group.
Results:
There was a positive correlation among all the measurements except the low- (LF) and high- (HF) frequency (LF/HF) ratio which was negatively correlated. The degree of correlation was stronger in some variables and weak in others.
Conclusion:
We have shown that time domain measures are correlated with frequency domain measures in both ASD patients and in healthy children. Some of these indices are so strongly correlated with each other that they can be used interchangeably.
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