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Published on: October 12, 2012
Flurbiprofen-induced generalized bullous fixed drug eruption
I Balta1, H Simsek, G G Simsek
11Department of Dermatology, Kecioren Training and Research Hospital, Ministry of Health, Ankara, Turkey.
Abstract:
Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.
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