Related Experiment Video
Updated: May 11, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Flurbiprofen-induced generalized bullous fixed drug eruption
I Balta1, H Simsek, G G Simsek
11Department of Dermatology, Kecioren Training and Research Hospital, Ministry of Health, Ankara, Turkey.
Human & Experimental Toxicology
|May 25, 2013
Summary
Fixed drug eruption (FDE) is a drug reaction causing recurring skin lesions. This case report details a rare instance of generalized bullous FDE triggered by flurbiprofen, a nonsteroidal anti-inflammatory drug.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Fixed drug eruption (FDE) is a recurring cutaneous adverse drug reaction.
- Commonly implicated drugs include antimicrobials, NSAIDs, and antiepileptics.
- Typical FDE presents as localized, erythematous patches or plaques.
Observation:
- A 50-year-old male presented with generalized bullous lesions.
- The patient's condition was linked to the use of flurbiprofen.
- This presentation represents a severe form of FDE.
Findings:
- Flurbiprofen, a nonsteroidal anti-inflammatory drug, induced a generalized bullous fixed drug eruption.
- This is the first reported case of flurbiprofen causing generalized bullous FDE.
- The severe presentation highlights potential underreporting of NSAID-induced FDE.
Implications:
- Clinicians should consider flurbiprofen as a potential cause of severe FDE.
- Awareness of NSAID-induced FDE is crucial for accurate diagnosis and management.
- Further investigation into NSAID-related FDE is warranted.
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