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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

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Related Experiment Video

Updated: May 11, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

The circadian clock and asthma.

Hannah J Durrington1, Stuart N Farrow, Andrew S Loudon

  • 1Faculty of Medical and Human Sciences, Institute of Human Development, , Manchester, UK.

Thorax
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Asthma symptoms worsen at night due to circadian variations in airway inflammation. Clock genes regulate these rhythms, offering potential new targets for asthma treatment.

Keywords:
AsthmaAsthma Mechanisms

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Last Updated: May 11, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Published on: November 11, 2016

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Area of Science:

  • Pulmonary Medicine
  • Chronobiology
  • Immunology

Background:

  • Nocturnal asthma symptoms, particularly cough and dyspnea, are common and indicate a need for treatment adjustment.
  • Circadian variations in airway inflammation, airflow limitation, and hyper-responsiveness are linked to nocturnal asthma symptoms.

Purpose of the Study:

  • To discuss how clock genes regulate circadian rhythms, focusing on the peripheral lung and immune clocks.
  • To explore the potential role of these clocks in asthma pathogenesis and treatment.

Main Methods:

  • Review of existing research on circadian variations in asthma.
  • Discussion of the molecular mechanisms of clock genes in central and peripheral tissues.
  • Focus on the peripheral lung clock and peripheral immune clock.

Main Results:

  • Clock genes are fundamental to circadian rhythm regulation.
  • Peripheral clocks exist in the lung and immune system.

Conclusions:

  • Circadian variations, regulated by clock genes, are integral to asthma.
  • Understanding the peripheral lung and immune clocks may reveal novel therapeutic strategies for asthma.