Related Experiment Video
Updated: May 11, 2026

Hybrid µCT-FMT imaging and image analysis
Published on: June 4, 2015
Hybrid imaging of peripheral skeletal disease by SPECT/high-resolution flat-panel CT
Christian Lohrmann1, Oliver Hauschild, Philipp T Meyer
1Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany. lohrmahnl@mskcc.org
Unlabelled:
The aim of this study was to determine the impact of high-resolution cone-beam CT with flat-panel detectors on the interpretation of bone SPECT in diseases of the peripheral skeleton.
Methods:
Forty-one consecutive patients with peripheral skeletal disease were examined with a SPECT/high-resolution CT system providing isotropic voxels of 0.33 × 0.33 × 0.33 mm. High-resolution images were retrospectively analyzed by 2 readers and compared with low-resolution images obtained by filtering the high-resolution images to a lower resolution.
Results:
SPECT/high-resolution CT demonstrated higher diagnostic confidence scores (1.98 ± 0.27 vs. 1.3 ± 0.45, P < 0.01) and better interobserver agreement (κ = 0.5 vs. 0.2) than SPECT/low-resolution CT. The diagnosis made by SPECT/high-resolution CT was in agreement with the final clinical diagnosis in 95% (reader 1) and 90% (reader 2) of the cases, as compared with 59% (reader 1) and 60% (reader 2) of the cases for SPECT/low-resolution CT (P < 0.01).
Conclusion:
High-resolution flat-panel CT has the potential to significantly improve SPECT/CT imaging in diseases of the peripheral skeleton.
More Related Videos
07:10A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
Published on: June 12, 2020
13:16Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
Published on: December 22, 2015
Related Concept Videos
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System V: CT
X-ray Imaging
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Ultrasonography
During an ultrasonography procedure, a handheld device called a...