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Chemokines, chemokine receptors and the gastrointestinal system

Hiroshi Miyazaki1, Kazuaki Takabe, W Andrew Yeudall

  • 1Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA. hmiyazaki@vcu.edu

World Journal of Gastroenterology
|May 25, 2013
PubMed

Insights

Chemokines, small immunomodulatory proteins, are increasingly recognized for their role in tumor progression and carcinogenesis. This review focuses on recent findings in chemokine biology within the gastrointestinal tract, highlighting potential therapeutic targets.

Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Tumor cell biology is influenced by cytokines and growth factors like epidermal growth factor receptor agonists and transforming growth factor β.
  • Chemokines, immunomodulatory proteins, are emerging as critical mediators of tumor progression.
  • Research suggests chemokines may play significant roles in carcinogenesis.

Purpose of the Study:

  • To review recent findings in chemokine biology.
  • To focus on the role of chemokines in the gastrointestinal tract.
  • To identify chemokines as potential therapeutic targets for cancer.

Main Methods:

  • Literature review of recent findings in chemokine biology.
  • Focus on studies related to the gastrointestinal tract.
  • Synthesis of information on chemokine function in carcinogenesis.

Main Results:

  • Chemokines are implicated as key players in tumor progression.
  • Chemokine involvement in carcinogenesis is increasingly evident.
  • The gastrointestinal tract is a significant area of chemokine research in cancer.

Conclusions:

  • Chemokines are crucial regulators of tumor cell properties.
  • Chemokines represent promising targets for novel cancer therapies.
  • Further research into gastrointestinal chemokine biology is warranted for therapeutic development.
Keywords:
CancerChemokineDigestive systemReceptorSignal transductionTargeted therapeuticsTumor progression

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