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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Updated: May 11, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

The adolescent with sickle cell disease.

Suvankar Majumdar1

  • 1Transitional Sickle Cell Clinic, University of Mississippi Medical Center, Jackson, MS, USA. smajumdar@umc.edu

Adolescent Medicine: State of the Art Reviews
|May 28, 2013
PubMed
Summary

Sickle cell disease (SCD) complications often begin in adolescence, requiring early detection and screening. This article guides primary care physicians on managing SCD organ issues and transitioning patients to adult care.

Area of Science:

  • Pediatric Hematology
  • Adolescent Medicine
  • Internal Medicine

Background:

  • Sickle cell disease (SCD) is frequently managed by primary care physicians, often focusing on acute pain.
  • Increasing life expectancy for SCD patients highlights the need for comprehensive care beyond pain management.
  • Numerous organ complications associated with SCD often manifest during adolescence.

Purpose of the Study:

  • To review organ complications in sickle cell disease, emphasizing adolescent onset.
  • To provide guidance on screening and detection strategies for these complications.
  • To address the critical transition of care from pediatric to adult health services.

Main Methods:

  • Literature review of organ complications in sickle cell disease.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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  • Discussion of screening protocols for adolescent SCD patients.
  • Overview of psychological impacts and transition processes for chronic illness management.
  • Main Results:

    • Sickle cell disease presents significant risks for organ damage, particularly during adolescence.
    • Proactive screening and early detection are crucial for managing SCD-related complications.
    • Transitioning care requires addressing both medical needs and psychological well-being.

    Conclusions:

    • Primary care physicians play a vital role in identifying and managing SCD organ complications in adolescents.
    • Effective transition strategies are essential for long-term patient health and quality of life.
    • Comprehensive, lifelong care is necessary for individuals with sickle cell disease.