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Updated: May 11, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Rapid progression of coronary artery stenosis revealed by stress echocardiography
Mariana Floria1, Antoine Guedes, Erwin Schroeder
1Department of Cardiology, CHU Mont-Godinne, Universite Catholique de Louvain, Yvoir, Belgium. floria_mariana@yahoo.com
Insights
Coronary artery disease can rapidly progress even without major risk factors. Dobutamine stress echocardiography is crucial for detecting significant stenosis in patients with initial findings of insignificant coronary atherosclerosis.
Area of Science:
- Cardiology
- Diagnostic Imaging
Background:
- Coronary atherosclerosis can present subtly, posing diagnostic challenges.
- The absence of major cardiovascular risk factors does not preclude rapid disease progression.
Observation:
- A 61-year-old woman presented with angina, palpitations, and dyspnea, despite prior angiography showing insignificant stenosis.
- Malignant ventricular arrhythmias were noted during angina episodes, with negative treadmill exercise testing.
- Dobutamine stress echocardiography revealed significant coronary artery stenosis, prompting re-angiography.
Findings:
- Re-evaluation confirmed rapid progression of stenosis in the proximal left anterior descending artery.
- Percutaneous coronary angioplasty with stenting was successfully performed.
- The case highlights the potential for rapid progression in seemingly low-risk patients.
Implications:
- Patients with initially insignificant coronary atherosclerosis require vigilant monitoring and aggressive risk factor management.
- Dobutamine stress echocardiography is a valuable tool for uncovering rapidly progressing coronary artery disease.
- Early detection and intervention are critical for favorable outcomes in these patients.
Abstract:
We present the case of a patient with initially insignificant coronary atherosclerosis with rapid progression revealed by dobutamine stress echocardiography, despite the absence of a major risk factor. A 61-year-old woman, complaining of chest pain, palpitations and dyspnoea on exertion, was referred to our department for outpatient assessment. Coronary angiography performed two months earlier revealed an insignificant stenosis of the proximal left anterior descending coronary artery. Holter monitoring revealed malignant ventricular arrhythmias during angina episodes.The results of maximal treadmill exercise testing were negative, but those of the dobutamine stress echocardiography were positive. The angiographic re-evaluation revealed a rapid progression of stenosis of the proximal left anterior descending coronary artery. Percutaneous coronary angioplasty with stenting was successfully performed.The outcome of patients with insignificant angiographic stenosis and no major risk factor is not necessarily favourable. Therefore, these patients should receive intensive therapy for the management of risk factors and careful clinical monitoring, including dobutamine stress echocardiography.
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