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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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4th Annual Predictive Toxicology Summit 2012.

Zhanfeng Cui1

  • 1Oxford University, Institute of Biomedical Engineering, Oxford Centre for Tissue Engineering and Bioprocessing, Department of Engineering Science, Oxford, UK. zhanfeng.cui@eng.ox.ac.uk

Expert Opinion on Drug Metabolism & Toxicology
|May 28, 2013
PubMed
Summary
This summary is machine-generated.

The 4th Annual Predictive Toxicology Summit highlighted advances in predictive toxicology. Bridging the gap between technology developers and pharmaceutical users is crucial for implementing new methods like stem cell assays and 3D tissue models.

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Area of Science:

  • Toxicology
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Summary of the 4th Annual Predictive Toxicology Summit 2012 held in London.
  • Meeting convened global pharmaceutical companies, SMEs, academic researchers, and regulatory bodies.

Purpose of the Study:

  • To summarize recent advances in predictive toxicology.
  • To identify key challenges and opportunities in the field.
  • To foster collaboration between technology developers and end-users.

Main Methods:

  • Presentations from industry, academia, and regulatory agencies.
  • Discussions on technological advancements and their applications.
  • Focus on novel in vitro models and assays.

Main Results:

  • Predictive toxicology is increasingly vital due to societal, economic, and scientific drivers.
  • Rapid technological progress exists, but a gap remains between developers and pharmaceutical users.
  • Emerging technologies include stem cell-derived assays and 3D in vitro tissue/organ models.

Conclusions:

  • Early engagement between technology developers and pharmaceutical end-users is essential.
  • Optimization and validation of new protocols and products are necessary.
  • The field requires interdisciplinary fundamental research, trained personnel, and adequate funding.