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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Quantitative evaluation of the stability and delivery of interleukin-1B by infusion

G C Visor1, K P Tsai, J Duffy

  • 1Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California.

Journal of Parenteral Science and Technology : a Publication of the Parenteral Drug Association
|May 1, 1990
PubMed

The stability and delivery of IL-1 beta has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion bags, at concentrations ranging from 100 ng/mL to 1 microgram/mL. At higher concentrations (1 microgram/mL), minimal drug loss was observed in both systems. At low doses (100 ng/mL) in the syringe-pump system, the addition of 1% human serum albumin was necessary to prevent significant drug absorption to the polypropylene drug reservoir.

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