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Epidemiological study of Landau-Kleffner syndrome (LKS) in Japan

Makiko Kaga1, Masumi Inagaki1, Reiko Ohta1

  • 1National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.

Brain & Development
|May 28, 2013
PubMed

Insights

This study estimates the incidence and prevalence of Kawasaki disease (LKS) in Japanese children. LKS affects approximately 1 in a million children aged 5-14, with a prevalence of 1 in 300,000-410,000 for those aged 5-19 under medical care.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Public Health

Background:

  • Kawasaki disease (LKS) is a significant pediatric illness.
  • Understanding the epidemiological landscape of LKS in Japan is crucial for public health initiatives.

Purpose of the Study:

  • To determine the incidence and prevalence of LKS in Japanese children.
  • To provide the first epidemiological estimation of LKS in Japan.

Main Methods:

  • A nationwide questionnaire survey was distributed to pediatric departments in Japanese hospitals.
  • Data on new and follow-up LKS patients were collected for the year 2008.
  • Vital statistics were used to calculate incidence and prevalence rates.

Main Results:

  • A response rate of 51.9% was achieved from 1562 pediatric departments.
  • Six new LKS cases (aged 6-14) and 32 follow-up cases were reported.
  • Estimated incidence for ages 5-14 was approximately 1 in 978,000.
  • Estimated prevalence for ages 5-19 under medical care ranged from 1 in 302,147 to 1 in 407,420.

Conclusions:

  • The incidence of LKS in Japanese children aged 5-14 is approximately 1 in a million.
  • The prevalence of LKS in Japanese children aged 5-19 under medical care is estimated between 1 in 300,000 and 1 in 410,000.
  • This study provides the foundational epidemiological data for LKS in Japan.
Abstract

Keywords:
EpidemiologyIncidenceJapanese childrenLandau–Kleffner syndrome (LKS)Prevalence

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