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Related Experiment Video

Updated: May 11, 2026

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
11:03

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Published on: November 10, 2015

Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation.

Marina Boccardi1, Martina Bocchetta2, Rossana Ganzola1

  • 1Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS - S. Giovanni di Dio - Fatebenefratelli, Brescia, Italy.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|May 28, 2013
PubMed
Summary
This summary is machine-generated.

Standardizing manual segmentation of the hippocampus for Alzheimer's disease (AD) biomarker measurement is crucial. This study reduced landmark variability into four units, improving reliability for AD-related atrophy assessment.

Keywords:
Alzheimer's Disease Neuroimaging InitiativeAlzheimer's diseaseAnatomic landmarkAtrophyDegenerationHarmonizationHippocampal atrophyHippocampal volumetryHippocampusMagnetic resonanceManual segmentation protocolManual tracingMedial temporal lobesNeuroimagingStandard operating procedures

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Last Updated: May 11, 2026

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Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Research
  • Biomarker Development

Background:

  • Hippocampal volumetry using MRI is a key Alzheimer's disease (AD) biomarker.
  • Manual segmentation is the gold standard but lacks standardized procedures.
  • Anatomic landmark variability hinders consistent measurement.

Purpose of the Study:

  • To operationalize and quantify landmark differences for consistent hippocampal segmentation.
  • To reduce variability across different manual segmentation protocols.
  • To inform a Delphi panel for establishing standardized landmarks.

Main Methods:

  • Reduced anatomic landmark variability from 12 protocols into four segmentation units: minimum hippocampus, alveus/fimbria, tail, and subiculum.
  • Expert raters segmented these units on MRI scans.
  • Assessed intra- and interrater reliability and contribution to AD-related atrophy.

Main Results:

  • High intra-rater (0.96) and inter-rater (0.92) reliability achieved for most units.
  • Alveus/fimbria showed lower reliability (0.86 intra, 0.77 inter).
  • Minimum hippocampus accounted for 67% of AD-related atrophy, followed by tail (24%).

Conclusions:

  • Anatomic variability in hippocampal segmentation protocols can be consolidated into four measurable units.
  • Quantitative assessment of these units aids in defining landmarks for a harmonized protocol.
  • Standardized segmentation will improve the reliability of hippocampal volumetry as an AD biomarker.