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Updated: May 11, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Pediatric sublingual immunotherapy efficacy: evidence analysis, 2009-2012

Désirée Larenas-Linnemann1, Michael Blaiss, Hugo P Van Bever

  • 1Hospital Médica Sur, Mexico City, Mexico. Marlar1@prodigy.net.mx

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 28, 2013
PubMed

Insights

Sublingual immunotherapy (SLIT) shows growing evidence for treating children's allergies. This review found robust efficacy for grass pollen SLIT and good evidence for house dust mite SLIT in asthma, with no anaphylaxis reported.

Area of Science:

  • Pediatric Allergy and Immunology
  • Immunotherapy Research
  • Clinical Evidence Synthesis

Background:

  • Sublingual immunotherapy (SLIT) is an alternative to subcutaneous immunotherapy for allergic diseases.
  • Evidence for SLIT's efficacy in pediatric populations requires ongoing evaluation.
  • Assessing the quality and scope of recent SLIT research is crucial for clinical practice.

Purpose of the Study:

  • To systematically analyze the latest scientific evidence on the clinical efficacy of SLIT in children.
  • To evaluate SLIT's effectiveness for various allergic conditions, including respiratory and food allergies.
  • To assess the quality of evidence and identify emerging trends in pediatric SLIT research.

Main Methods:

  • Comprehensive literature search of PubMed, Embase, and other databases (2009-2012).
  • Inclusion of original articles on clinical trials of SLIT in patients under 18 years.
  • Quality assessment using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.

Main Results:

  • 29 trials met inclusion criteria, showing robust evidence for grass pollen SLIT in allergic rhinitis.
  • High-quality evidence supports house dust mite (HDM) SLIT for medication reduction in pediatric asthma.
  • Moderate evidence suggests efficacy for dual grass pollen-HDM SLIT; food SLIT shows less promise than oral immunotherapy.

Conclusions:

  • The body of evidence supporting the efficacy of SLIT in children with respiratory and food allergies is expanding.
  • SLIT demonstrates potential for managing allergic rhinitis and asthma in pediatric patients.
  • Further research is needed to solidify evidence for specific allergens and food allergies.
Abstract

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