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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Published on: March 14, 2017

Alternatives to blood transfusion.

Donat R Spahn¹, Lawrence T Goodnough

¹Institute of Anaesthesiology, University and University Hospital Zurich, Zurich, Switzerland. donat.spahn@usz.ch

Lancet (London, England)

|May 28, 2013

Summary

Alternatives to allogeneic blood transfusions are increasingly favored due to risks and costs. Patient outcomes and cost-effectiveness will drive the adoption of blood alternatives in managing anemias.

Area of Science:

Transfusion Medicine
Anemia Management

Background:

Allogeneic blood transfusions carry inherent risks and significant costs.
Healthcare systems face challenges with blood inventory management and transfusion-related adverse outcomes.

Purpose of the Study:

To review the current roles of alternatives to blood transfusion in managing medical and surgical anemias.
To evaluate the cost-benefit profiles and risk-benefit profiles of various blood alternatives.

Main Methods:

Literature review of studies on alternatives to blood transfusion.
Analysis of cost-effectiveness and risk-benefit data for blood conservation strategies.

Main Results:

Evidence suggests a decline in blood use due to costs and adverse outcomes.

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Cost and patient outcomes are key drivers for the adoption of blood alternatives.

Risk-benefit profiles of autologous blood, erythropoiesis-stimulating agents, and hemostatic agents are under investigation.

Conclusions:

Rising blood costs and inherent transfusion risks support the continued development and use of blood alternatives.
Alternatives to blood transfusion are crucial for managing medical and surgical anemias effectively.