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Updated: May 11, 2026

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

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Published on: September 27, 2019

MCM loading--an open-and-shut case?

Rachel Y Samson¹, Stephen D Bell

¹Department of Molecular and Cellular Biochemistry, Indiana University, Simon Hall MSB, 212 S Hawthorne Drive, Bloomington, IN 47405, USA.

|May 28, 2013

Summary

This summary is machine-generated.

Two studies reveal crucial steps in loading the yeast replicative helicase MCM(2-7). These findings clarify essential interactions for DNA replication initiation and maintenance.

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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

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Published on: January 11, 2018

Area of Science:

Molecular biology
Cellular processes
DNA replication

Background:

The replicative helicase MCM(2-7) is essential for DNA replication.
Understanding its loading mechanism is key to comprehending cell cycle control.
Previous models proposed various loading pathways.

Purpose of the Study:

To elucidate the precise molecular events and protein interactions during the loading of the budding yeast MCM(2-7) helicase.
To provide a detailed mechanistic understanding of replicative helicase assembly.

Main Methods:

Utilized biochemical assays to study protein-protein interactions.
Employed genetic manipulation in budding yeast models.
Integrated data from complementary studies.

Main Results:

Identified key protein factors and their temporal order in MCM(2-7) loading.
Dissected specific interactions critical for helicase complex formation.
Provided a refined model for the Mcm2-7 loading pathway.

Conclusions:

The loading of the MCM(2-7) helicase is a highly regulated, multi-step process.
These studies offer significant insights into the initiation of DNA replication.
The findings have implications for understanding genome stability.