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Updated: May 11, 2026
08:31
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
Published on: May 26, 2013
Virome genomics: a tool for defining the human virome
Kristine M Wylie1, George M Weinstock, Gregory A Storch
1The Genome Institute, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St. Louis, MO 63108, United States. kwylie@genome.wustl.edu
Current Opinion in Microbiology
|May 28, 2013
Summary
Deep sequencing assays offer powerful insights into virus-host interactions, enabling discovery of new viruses and characterization of viral genomes and host responses. This review highlights recent advances in sequencing technologies for studying viral evolution and infection dynamics.
Area of Science:
- Virology
- Genomics
- Infectious Diseases
Background:
- High-throughput sequencing assays are crucial for understanding virus-host interactions.
- These methods allow for the discovery of novel viruses and detailed genomic characterization.
- Sequencing provides insights into host gene responses and viral gene expression during infection.
Purpose of the Study:
- To review major advances in virus-host interaction studies over the past two years.
- To discuss the application of sequencing technologies in this field.
- To highlight the role of sequencing in understanding viral evolution and host responses.
Main Methods:
- Deep sequencing assays
- Genomic analysis
- Gene expression profiling
- Comparative genomics
Main Results:
- Sequencing facilitates novel virus discovery and genome description.
- Genomic data aids in predicting viral proteins and identifying key host genes.
- Analysis of viral and host gene expression reveals infection dynamics.
- Sequencing captures viral variation and evolution during replication and transmission.
Conclusions:
- Deep sequencing is a transformative technology in virology research.
- It provides a comprehensive understanding of virus-host dynamics, evolution, and infection.
- Continued advancements in sequencing will further enhance our ability to combat viral diseases.
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