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Related Experiment Video

Updated: May 11, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Associations between dietary patterns and kidney function indicators in type 2 diabetes.

Chih-Cheng Hsu¹, Huei-Ru Jhang², Wen-Tsan Chang³

¹Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; Department of Health Services Administration, China Medical University and Hospital, Taichung, Taiwan.

Clinical Nutrition (Edinburgh, Scotland)

|May 28, 2013

Summary

A diet rich in vegetables and fish may support kidney function in adults with type 2 diabetes. This dietary pattern was associated with lower creatinine and improved estimated glomerular filtration rate (eGFR).

Keywords:

Albuminuria Chronic kidney disease Dietary patterns Nephropathy Type 2 diabetes

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Area of Science:

Nutrition Science
Nephrology
Endocrinology

Background:

Dietary patterns are associated with chronic disease risks.
Limited research exists on dietary patterns and kidney function in Asian adults with type 2 diabetes.

Purpose of the Study:

To investigate the relationship between dietary patterns and kidney function indicators in adult type 2 diabetes patients in Taiwan.

Main Methods:

A cohort of 635 diabetic patients in Taiwan was analyzed.
Factor analysis identified three dietary patterns: high fat, vegetable and fish, and traditional Chinese-snack.
Kidney function was assessed using urinary albumin to creatinine ratio (ACR), creatinine, and estimated glomerular filtration rate (eGFR).

Main Results:

The vegetable and fish dietary pattern showed a significant dose-response correlation with decreased creatinine and marginally increased eGFR.
The traditional Chinese-snack dietary pattern had a marginal association with creatinine and eGFR.
High fat dietary patterns were not correlated with any kidney function indicators.

Conclusions:

Frequent intake of fish and vegetables may be linked to better kidney function indicators in type 2 diabetes.
Further research with larger sample sizes and sensitive renal function indicators is recommended to confirm these findings.