Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 11, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Probabilistic functional tractography of the human cortex.

Olivier David1, Anne-Sophie Job, Luca De Palma

  • 1Fonctions Cérébrales et Neuromodulation, Université Joseph Fourier, Grenoble, France. odavid@ujf-grenoble.fr

Neuroimage
|May 28, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.

Nature communications·2026
Same author

Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Pediatric epilepsy surgery: Global survey of invasive explorations.

Epilepsia·2026
Same author

[<sup>18</sup>F]FDG PET/MRI in Pediatric Focal Epilepsies.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.

bioRxiv : the preprint server for biology·2026
Same author

Frontal Disconnection in a Case of Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy.

World neurosurgery·2026

This study introduces a novel neuroimaging framework to map human brain connectivity using direct electrical stimulation. The developed atlas reveals directional and timed cortico-cortical connections, advancing our understanding of brain networks.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Computational Biology

Background:

  • Focal drug-resistant epilepsy patients undergoing intracranial electrode exploration offer a unique opportunity to study brain connectivity.
  • Direct electrical stimulation of the cortex generates measurable potentials reflecting functional and anatomical connections.

Purpose of the Study:

  • To develop a novel neuroimaging framework for creating a probabilistic atlas of functional tractography in the human cortex.
  • To enable in vivo inference of directionality and latency of cortico-cortical connectivity, which is currently limited.
  • To provide a freely distributable resource for understanding and modeling large-scale brain networks.

Main Methods:

  • Utilized single-pulse direct electrical stimulation in 35 adult epilepsy patients (1535 stimulation runs).
Keywords:
Brain atlasEpilepsyIntracranial electroencephalogramNeuroimagingSignal analysis

More Related Videos

Neuroimaging-Guided TMS&#8211;EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Related Experiment Videos

Last Updated: May 11, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Neuroimaging-Guided TMS&#8211;EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

  • Developed a probabilistic atlas of functional tractography based on induced cortico-cortical potentials.
  • Employed a neuroimaging framework to analyze stimulation responses for connectivity inference.

    • Main Results:

    • Demonstrated asymmetrical connectivity between the posterior hippocampal gyrus and orbitofrontal cortex in a frontal lobe epilepsy case.
    • Showcased probabilistic functional tractography between the posterior superior temporal gyrus and inferior frontal gyrus as a proof of concept.
    • Established a method for in vivo inference of cortico-cortical connection directionality and latency.

    Conclusions:

    • The developed framework and atlas offer unprecedented in vivo insights into human brain connectivity.
    • This approach provides critical information for advancing the understanding and modeling of complex brain networks.
    • The probabilistic maps will be shared to foster further research in neuroscience and clinical applications.